一、承办院系School/Department host:
深圳国际研究生院
Tsinghua Shenzhen International Graduate School
生物医药和健康工程研究院
Institute of Biopharmaceutical and Health Engineering
二、挑战主题Theme:
微生物合成工厂的应用和挑战
Applications and Challenges of Synthetic Biology in Microbial Cell Factories
三、导语/背景情况概述Background:
通过合成生物学技术，改造微生物基因元件和代谢环路，可以实现化合物的大规模绿色生物合成，将极大变革传统的化工产业和微生物发酵工业，近年来在化工、医药、能源等领域广泛应用。但是，生物合成在科学技术、成本、伦理、安全和法规上还面临着很大挑战，比如底盘细胞的构建，安全性如何保证等等。
希望通过本次比赛，经过跨学科领域的思考，寻找应用微生物合成工厂面临广泛挑战的合理解决方案
With the emerging technology of synthetic biology, we can design and synthesize genetic circuits to facilitate mass and green production of molecules, which has been widely used in the industry of chemical engineering, biopharmaceuticals and energy, and will revolutionize the traditional industry. However, the application has faced great challenges, including in terms of science and technology, cost, ethics, safety and laws. For example, how can we design and construct a chassis cell? How can we ensure safety?
In this Hack, we aim to think in a comprehensive and interdisciplinary manner to search for solutions for the application of synthetic biology in microbial cell factory.
四、该领域比较关注的问题Our key topics of interest:
微生物合成工厂应用面临的科学和技术问题
Scientific and technological issues of synthetic biology in microbial cell factories
合成生物学应用的安全和伦理问题
Safety and ethics issues in synthetic biology
五、主讲老师Hack Leader
Dr. Lan Ma received a B.Sc. degree in genetics from Wuhan University, Wuhan, China, in 1987, the M.Sc. degree in immunology from Peking University, Beijing, China, in 1993, and the Ph.D. degree in stem cell biology from the Chinese Academy of Sciences, China, in 2003. She was associate professor at Yunnan University from 2000 to 2005 and Tsinghua Shenzhen Graduate School from 2005 to 2011. Since 2012, she has been a professor at the Tsinghua Shenzhen Graduate School. Her research interests include stem cell biology, nano-biomedicine, and vaccine & antibody bio-engineering.
LIU Xiao received his bachelor and master degree in Nanjing University in China majoring in chemistry and molecular biology, respectively. He received a PhD degree in University of Copenhagen, Denmark. He joined as an associate professor at the Tsinghua University Shenzhen International Graduate School in 2020. His current research interests include system human immunology with an emphasis on deciphering the heterogeneity and multimodality of the human immune microenvironment.
六、导师Mentors
Yan Zhao is currently an assistant researcher of the Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory. She was awarded a Ph.D. degree by Shanghai Institute of Applied Physics, Chinese Academy of Sciences in 2017. She then engaged in postdoctoral research in Prof. Chunhai Fan’s group. Her research interests generally concern the biological applications of DNA nanotechnology. She specializes in the design and assembly of framework nucleic acid nanomachines, functionalized nucleic acid modification, bioimaging and disease diagnosis and treatment based on DNA nanostructures. She has published academic papers in Angewandte Chemie International Edition, Nano Today, ACS Applied Materials and Interfaces, Nature Communications and other high-level journals. She has been funded by the China Postdoctoral Science Foundation. She also participated in several National Natural Science Foundation projects and National Key Research and Development programs.
Taosha Li is the secretary-general of the Belt and Road Life Science Economy Alliance (LSEA) and Life-Tech Industry Alliance. She was the Science and Technology Partner and the head of policy and regulations of Miracle Light (Shenzhen) Co., which is an incubator invested by companies including BGI, Green Pine Capital Partners, and Cowin Capital. Taosha Li was a project leader in the Shenzhen Leaguer Angel Venture Capital Management Co., Ltd. - a very famous angel venture capital company in China. Taosha Li was a District Sales Manager in Life Technologies - a Global Top Bio-company - in charge of the business of SIB in Southern China. Taosha Li was a team leader of samples collection in Southern Chinese pedigree for the 1000 Genomes Project. She spent 5 years studying and working in UK. During that time, she graduated with an Msc from the Clinical Oncology Department of the University of Nottingham in 2004, and opened and managed a Traditional Chinese Medical Clinic and a training service company in UK. Taosha Li gained an MB of Clinical Medicine in 2002.
七、承办院系简介
生物医药与健康工程研究院关注健康与工程技术融合，用以应对健康中国及深圳生物科技产业面临的实践和发展挑战。学院有国际一流交叉学科中心，健康产业关键核心技术平台，设有药学、生物工程、生命科学、医学、化工、生物材料等共享设备中心。目前学院聚焦五大方向：健康工程、制药工程、疫苗工程、细胞工程、生物大数据。
The Institute of Biopharmaceutical and Health Engineering (iBHE) explores the frontiers of health technology and engineering for human wellbeing to meet the practical needs and long-term development strategy for the building of a “Healthy China” and promoting Shenzhen’s biotechnology industry. The Institute builds international first-class disciplines for providing comprehensive scientific solutions and awareness-based revolutionary technologies for human health and happiness by integrating pharmaceutical engineering, bioengineering, life sciences, medical sciences, chemical engineering, process and system engineering, materials engineering and other advanced discipline clusters. iBHE focuses on the development of five main aspects: health engineering, pharmaceutical engineering, vaccine manufacturing, biomedical big data, and cell engineering.
